Sitangkai is a municipality in the province of Tawi-Tawi. Located about 14 kilometers east of the coast of Sabah, Malaysia. It is the southernmost municipality of the Philippines.

It is called the 'Venice of the Philippines' due to the use of boats as primary transportation, although footbridges connect one house from another.

The major sources of livelihood are fishing and farming, although there is very sparse agricultural land available.

According to the 2000 census, it has a population of 52,772 people in 8,969 households.

Sitangkai was created as a municipality on August 26, 1959 by virtue of Executive Order No. 355 of Pres. Carlos P. Garcia. On October 21, 2006 with the ratification of Muslim Mindanao Autonomy Act No. 197, 16 of its 25 barangays were transferred to the newly created municipality of Sibutu. All of which are located on Sibutu Island.

Sitangkai is politically subdivided into 9 barangays.

The place has two seasons: dry and wet The climate is generally moderate. The wettest months are from August to November. The other months of the year are generally dry with occasional rain showers.